6 Must Try Regional Sandwiches

Posted on: 5 July 2016

If you're planning on going on a road trip across the country, one of the most important cultural touchstones to experience is regional cuisine. Every state is home to some very unique food – especially when it comes to sandwiches! Listed are just a few singular sandwiches you have to try!


An absolutely simple and delicious Massachusetts delight. The fluffernutter consists of marshmallow cream and peanut butter sandwiched between two pieces of white bread. It can be prepared in approximately a minute and is considered the comfort food of many a Bostonian.

Beef on Weck

The beef on weck is a culinary invention of German immigrants to upstate New York, particularly the Buffalo area. It is roast beef served on a kümmelweck roll with a side of au jus sauce. In addition to the au jus, the perfect beef on weck also demands heavy salt, horse radish, and a few dill pickles to top it off.

Brain Sandwich

If you find yourself in Evansville, Indiana, do yourself a favor and stop in at one of the many restaurants that serve brain on a bun. Although it mind sound a bit strange, this egg battered and deep fried cow brain sandwich was, much like the beef on weck, the invention of German immigrants to the area. It is often served on a kaiser roll and served with onions, dill pickles, and lettuce.

Hot Fish Sandwich

Nashville's hot fish sandwich is a deceptively simple southern treat. White fish that has been deep fried is seasoned with cayenne pepper, which makes this dish not only hot but spicy. It is then placed between two pieces of white bread and served with onion, pickle, ketchup, mustard, and if you want to add even more spice to the equation, hot sauce.

Loose Meat Sandwich

Endemic to the Midwest, the loose meat sandwich is similar to a Sloppy Joe, except the ground and crumbled beef that is sandwiched between the bun lacks the sauce. The perfect loose meat sandwich is often times served with dill pickles and mustard, and occasionally onion.


The spiedie is a sandwich that derives its name from the Italian term for meat that is served on a skewer. As you could have guessed, the spiedie is an Italian roll that is served with meat – usually chicken or lamb – on skewers. The meat has been marinated, and you pull it off at your leisure to construct your own sandwich.